In vitro and in vivo antioxidant and antihyperglycemic potentials of phenolic fractions of <i>Syzygium zeylanicum</i> (L.) <scp>DC</scp> trunk‐bark

Syzygium zeylanicum L. (DC) (SZL) has been used in antidiabetes treatment for ages. However, the scientific evidence of active agents that have antidiabetic activity and response against biological activities is limited. In this study, components SZL trunk-bark extract (SZL extract) were identified using principal component analysis (PCA), their assessed. The results indicated ethyl acetate fraction (EAF) had highest concentration phenolic compounds, antioxidants, antihyperglycemic postprandial zebrafish model. major antioxidant contributors gallic acid, catechin, epicatechin, ellagic quercetin, caffeine, apigenin, concentrated levels reduced α-amylase inhibitory activity, whereas rutin gallate influenced α-glucosidase activity. This study showed bio-functional properties compounds present extract, potentially serving as a functional food to control hyperglycemia.